Endocrine Abstracts

Hypophysitis is an inflammatory disorder of the pituitary gland and among them, IgG-4 hypophysitis is rare and presents in less than 5 % of cases.Case: 59 years old lady with a past medical history of asthma presented Rheumatology with? giant cell arthritis due to constant frontal headache, pain behind her eyes, and raised inflammatory markers (ESR 15, CRP 17) three weeks after COVID infection. After review, rheumatology team concluded unlikely giant cel...

Introduction: Crooke’s cell adenomas are nonneoplastic corticotropes with cytoplasmic accumulation of cytokeratin filaments in response to glucocorticoid excess. They are rare subtype of corticotrope adenomas presenting less than 1 % of pituitary adenomas.Case: 52 years old man attended Ophthalmology Clinic with 2 months history of right-sided reduced vision. He had a history of posterior polymorphous corneal dystrophy with a left corneal transplant...

A 46 years old gentleman was referred by his GP to cardiology with 3 weeks history of bilateral leg swelling and rash associated with breathlessness and palpitations. He has no other past medical history to note. He smokes 20 cigarettes a day and works as a manager in a window installation company. He was started on diuretics and further investigations were arranged by cardiology. His symptoms persisted with worsening of skin rash. He was reviewed by GP again 1 month later. He...

Pituitary apoplexy is a rare but life threatening condition if not diagnosed and treated promptly. Common causes include hypertension, head trauma, major surgery, dynamic pituitary tests, anticoagulant use and pregnancy. In pregnancy, hyperplasia and hypertrophy of the lactotroph cells increase pituitary volume by 45% returning to original size at 6 months post-partum. Pituitary apoplexy is uncommon in pregnancy and an underlying adenoma is usually the cause. Very few...

Grave’s disease is an auto-immune condition associated with hyperthyroidism caused by TSH-receptor antibodies (TRAB) expressed by follicular cells of the thyroid gland. Grave’s ophthalmopathy has been reported in 25% of the patients and is rarely associated with dermopathy and thyroid acropachy. Management is by anti-thyroid drugs, radioactive iodine ablation or surgery, either alone or in combination. We present a rare case of resistant Graves who has detectable ant...

A 50 year old male presented with left visual field loss, afferent pupillary defect and reduced libido in 1999. Initial pituitary profile showed prolactin 130 000 mu/l (55.4–276), and testosterone was 5 nmol/l (10–27.6). MRI pituitary showed giant pituitary macroadenoma compressing chiasm. He was started on Cabergoline with subsequent improvement in visual fields, prolactin levels and size of adenoma on subsequent MRI. His disease remained stable on ...